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Measurement of the radioactivity of man by whole body counting will give considerable information about body composition and metabolism which either cannot be determined by other means or can be determined only with greater hazard or difficulty. Exchangeable sodium can be measured repetitively for as long as four months after injection of a single tracer dose; thyroid uptake can be measured with a small fraction of conventional doses; the whole body content of a nuclide can be measured, as well as blood levels, respiratory, urinary, and fecal excretion rates and differences in concentration in different organs and within a single organ. The greatest value of in vivo counting techniques may be the calibration of other techniques of bioassay such as breath and urine measurements, so that the counting of excretory product as a function of time can be used as an index of the total body burden of the isotope
Wehrmacher WH. Radioactivity in Man: Whole Body Counting and Effects of Internal Gammaray Emitting Radioisotopes.. Arch Intern Med. 1965;116(4):625. doi:10.1001/archinte.1965.03870040139034