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November 1965

Animal and Clinical Pharmacologic Techniques in Drug Evaluation.

Author Affiliations

Edited by J. Nodine, MD, and P. E. Siegler. Price, $18. Pp 660, with 108 illustrations. Year Book Medical Publishers, Inc., 35 E Wacker Dr, Chicago, Ill 60601, 1964.

Arch Intern Med. 1965;116(5):792-793. doi:10.1001/archinte.1965.03870050146027

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The Halneman Medical College and Hospital, Philadelphia, training program in clinical pharmacology consists in part of a formal course given as guest lectures and entitled "Clinical Pharmacological Techniques." This book represents the material of this course. A total of 92 authors contribute to 87 chapters; most of the authors come from Philadelphia but there are conspicuous contributions from members of the pharmaceutical industry.

The first few chapters deal with such important and fundamental topics as the kinetics of absorption, distribution, excretion, and metabolism of drugs, statistical problems in the planning and performance of clinical trials, and variability in drug response. There is also a rather limited introductory chapter on the general considerations and objectives of clinical pharmacology. The remainder of the book consists of chapters on animal and clinical techniques for the evaluation of a wide variety of drug groups, ranging from anesthetics to laxatives. The animal methods for a

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