THE POSSIBILITY that the adrenal and pituitary glands play an important role in bronchial asthma has been suggested by many investigators.
Rackemann in 1945 reported low levels of urinary 17-ketosteroids in patients with bronchial asthma.1 Since then many investigators have noted similar findings.2-5 Rose et al, in a study of 58 asthmatic patients, showed that there was a diminished urinary glucocorticoid excretion which persisted as long as the asthmatic attack.6 Spaner and associates7 concluded that urinary 11-hydroxysteroids are reduced during an asthmatic attack. Low levels of 17-ketosteroids and normal levels of plasma 11-oxysteroids have been reported by Lemon et al in their study of patients with asthma.8 Recently Vaccarezza has reported low 17-ketosteroids and normal 17-hydroxysteroids in asthmatic patients.9
Normal urinary 17-hydroxysteroids and 17-ketosteroids in patients with asthma have been reported by others.10,11 Siegel et al12 and Vaccarezza 9 found normal plasma Cortisol levels in asthmatic patients. Evaluation of
BLUMENTHAL MN, McLEAN JA, MATHEWS KP, SHELDON JM. Adrenal-Pituitary Function in Bronchial Asthma. Arch Intern Med. 1966;117(1):34-38. doi:10.1001/archinte.1966.03870070048006