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February 1966

The Treatment of Cancer With Special Reference to Radiotherapy and Chemotherapy.

Arch Intern Med. 1966;117(2):313. doi:10.1001/archinte.1966.03870080157035

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This book is a collection of papers and discussions from a course held at the University of Cambridge. The lecturers represent investigators in the treatment of cancer from hospitals or research institutes in England, Germany, Israel, and Hong Kong, but are chosen predominantly from the Cambridge faculty. The emphasis is on recent chemotherapeutic drugs and their uses, radiologic techniques, and radiotherapy. There is an ample discussion of mechanism of action and avenues of future investigation.

The lead-off discussion (F. Bengel) reviews work on the different mechanism of several groups of alkylating agents followed by a superb review of the pharmacology of nitrogen mustard and its derivatives, such as busulfan and chlorambucil (A. L. Walpole). A speculative discussion of folic acid antagonists in acute leukemia of children (W. Jacobson) includes work indicating differences in metabolic activity of normal and leukemic cells. The very important subject of blood supply to large tumors

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