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February 1966

The Action of Neuroleptic Drugs.

Arch Intern Med. 1966;117(2):314-315. doi:10.1001/archinte.1966.03870080158038

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This book consists of two parts—a 159page part by Haase on clinical observations on the action of neuroleptic drugs and an 11page part by Janssen on their pharmacology.

Our understanding of a neuroleptic drug in the United States is one which mimics symptoms resembling those found in diseases of the nervous system. Janssen (quoting J. Delay and P. Deniker Méthodes chimiothérapiques en psychiatrie, Masson et Cie, Paris, 1961) lists neuroleptic drugs as (1) psychic sedatives as barbiturates, chlorpromazine, meprobamate, (2) psychic stimulants (or psychoanaleptic drugs) as amphetamine, iproniazid, imipramine, strychnine, (3) psychodelic or hallucinogenic drugs. With that definition it appears to me that virtually all psychotropic drube—in leptic. That they may well be—in larger doses which call forth their familiar side-effects. The author states that since neuroleptic drugs produced the same symptoms or symptom-equivalents in man and in other animals, laboratory animals can thus be used in assessing the neuroleptic

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