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March 1966

Estrogen PharmacologyIII. Effect of Estradiol on Plasm Disappearance Rate of Sulfobromophthalein in Man

Author Affiliations


From the Department of Medicine, University of Chicago, and the Argonne Cancer Research Hospital.

Arch Intern Med. 1966;117(3):373-376. doi:10.1001/archinte.1966.03870090057009

ESTRADIOL depresses the hepatic secretory transport maximum (Tm),1,2 for sulfobromophthalein (BSP) in man.3 In rats, this hormone similarly delays hepatic removal from plasma of both BSP and the dye phenol-3,6-dibromophthalein disulfonate,4 a chemical analog of BSP which does not undergo conjugation during hepatic transit into bile.5 The latter finding indicated that, in this experimental context, estrogens act on hepatic processes other than those concerned with dye conjugation, and implied that the BSP retention induced by these hormones in man reflected a decrease in the net rate of hepatic disposal not only of the conjugated form of BSP, but of the free dye as well. The present study was undertaken to examine this possibility by analysis of the BSP components in the plasma of estrogen-treated subjects at appropriate intervals after intravenous injection of the dye. The results confirm that in man the net movement of both free and conjugated BSP out

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