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March 1966

Thyroid Carcinoma Occurring in Graves' Disease

Author Affiliations


From the 2845th USAF Hospital, Griffiss AFB, NY, the Radioisotope Service, Veterans Administration Hospital, and the Department of Medicine, State University of New York, Upstate Medical Center, Syracuse, NY.

Arch Intern Med. 1966;117(3):432-435. doi:10.1001/archinte.1966.03870090116023

THYROID carcinoma occurring with Graves' disease has been rarely reported and is not commonly considered in persons with hyperthyroidism. However, on the basis of statistical studies, it has been suggested that there is a greater incidence of thyroid carcinoma in hyperthyroid than in euthyroid states.1 Since 131I and antithyroid drugs are common means of treating hyperthyroidism, it is possible that cases of carcinoma occurring in hyperthyroid persons are going undetected, and consequently, untreated.

Report of a Case  A 21-year-old male Negro was first seen because of exophthalmos of three to four months' duration. Symptoms of weight loss despite a good appetite, fatigue, and mild nervousness were elicited. There was no past history of radiation exposure to the neck area and no family history of thyroid disorder.Physical examination revealed a well-nourished man, 6 ft 1 in (185.5 cm) tall, weight 186 lb, pulse rate 100 per minute. The

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