March 1966

Genetics and Disease.

Author Affiliations

By Alfred G. Knudson, Jr., MD, PhD in Biochemistry and Genetics. Price, $10.50. Pp 294. The Blakiston Division of McGraw-Hill Book Co., Inc., 330 W 42nd St, New. York, NY 10036, 1965.

Arch Intern Med. 1966;117(3):464-465. doi:10.1001/archinte.1966.03870090148036

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This book is by no means an extended treatise on clinical genetics, but rather a discussion of the genetic implications of several very large areas of clinical medicine including cytogenetic syndromes, X-linked diseases and linkage, inborn errors of metabolism, molecular disease, infection and immunity, cancer, and degenerative diseases and aging. These sections are preceded by a chapter on Mendelism (with some population genetical considerations) and on phenogenetics.

The first chapter conveys rather vividly the general nature of the book. It is obviously written by an astute and articulate scholar (BS California Institute of Technology, MD Columbia University College of Physicians and Surgeons, Pediatrician, Fellow Children's Hospital, Los Angeles, Guggenheim Fellow, National Foundation Fellow, PhD Biochemistry and Genetics, in 1956 chairman Department of Pediatrics, City of Hope) and yet it tries to do too much in too few pages. It attempts to convey the essence of a major portion of an

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