EXTENSIVE experience with tetracycline has led to the general conclusion that serious toxic effects are very unusual. However, cases of hepatic disease associated with tetracycline have been reported recently.1-9 The first reports were of pregnant Negro women with infection of the urinary tract; later reports included less well documented cases in a man,9 a child,3 and nonpregnant women.3,6
Another potentially fatal side effect of this antibiotic drug is nephrotoxicity. Acute renal failure associated with tetracycline is not accompanied by oliguria. In the presence of a normal urine volume, increasing azotemia is easily overlooked as a possible cause for rapid deterioration of a patient. Hepatic disease associated with this drug is frequently accompanied by renal failure, which may be overlooked because the clinical manifestations of hepatic failure are more striking. A case of a pregnant woman with acute hepatic and renal failure without oliguria is reported.
Report of a Case
LEW HT, FRENCH SW. Tetracycline Nephrotoxicity and Nonoliguric Acute Renal Failure. Arch Intern Med. 1966;118(2):123-128. doi:10.1001/archinte.1966.00290140027006