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September 1966

Bone Metastasis in Osteogenic Sarcoma

Author Affiliations


From the Department of Epidemiology and Microbiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh. Formerly Epidemic Intelligence Service Officer, US Public Health Service, Communicable Disease Center, and Assistant Research Professor of Epidemiology, University of Pittsburgh, Graduate School of Public Health, and presently resident, Second (Cornell) Medical Division, Bellevue Hospital, New York (Dr. Lockshin).

Arch Intern Med. 1966;118(3):203-204. doi:10.1001/archinte.1966.00290150017005

THE IMPORTANCE of bone as a site of metastasis in osteogenic sarcoma is seldom emphasized. The recent observation of five patients with osteogenic sarcoma and bone metastases in Allegheny County, Pa, within one year 1 suggested an investigation to determine how frequently bone metastases occur in patients with this tumor.

Methods  Death certificates of all persons dying in Allegheny County from 1953 through 1964 of primary bone malignancy were abstracted. These certificates identified 186 persons, 95 of whom died in a local hospital. The hospital charts of 92 of these patients were reviewed; three charts could not be located. From the pathologist's reports available in the charts, each patient was classified as having or not having osteogenic sarcoma. Cases without pathological examination were excluded. All cases having osteogenic sarcoma were then subclassified by histological type in a manner similar to that suggested by McKenna.2 Each hospital chart was

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