September 1966

Basophilic Leukemia

Author Affiliations


From the Mayo Clinic and Mayo Foundation: Section of Medicine (Dr. Kyle), and of Clinical Pathology (Dr. Pease).

Arch Intern Med. 1966;118(3):205-210. doi:10.1001/archinte.1966.00290150019006

ALTHOUGH basophilic leukemia was described almost 60 years ago,1 few bonafide cases have been reported in the English literature.2-5 The last case reported in this country was in 1946. We have recently observed a patient with basophilic leukemia and after searching the files of the Mayo Clinic have found another. In view of the rarity of this entity we are presenting these two cases.

Report of Cases 

Case 1.  —This 45-year-old white farmer was well until fatigue developed in April 1964. He saw his physician who found a leukocytosis and sent him to this clinic. The patient had no symptoms other than fatigue. Physical examination gave normal results except that the liver and spleen extended three fingerbreadths below the right and left costal margins, respectively. The hematologic values are listed in Table 1. Blood urea measured 21 mg/100 ml and uric acid measured 8.0 mg/100 ml. A routine

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