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To praise this book would be gilding the lily. To outline what it contains would be almost superfluous as it is well known to be a most comprehensive pharmacology text, embellished by many peripheral yet important facets which lend it comprehensiveness. To state how it presents its material and for what particular purpose it is most suitable would perhaps be more germane.
Before Goodman and Gilman's first edition appeared, Sollmann's Manual of Pharmacology was the pharmacologist's pharmacology text. It gave details on a variety of effects some of which were of recondite properties of drugs then used. The appearance of Goodman and Gilman's text put the strong emphasis of pharmacology upon therapy and how the pharmacological effect of drugs can be utilized in therapy or is limited in therapeutic use.
In the process, many of the older drugs were justifiably dropped. For example, there is no trace in Goodman and
Di Cyan E. The Pharmacological Basis of Therapeutics.. Arch Intern Med. 1966;118(6):615-617. doi:10.1001/archinte.1966.00290180091025