In RECENT years, the relationship between congenital malformations and chromosomal abnormalities has been well established. The present paper describes a mentally retarded girl with multiple congenital anomalies and a 1/G translocation. In addition, five members of the kindred in three consecutive generations had an abnormal G chromosome.
Report of Case
A 5-year-old white girl was brought to our attention in August 1965 because of somatic and mental retardation. She was the product of a full-term gestation, weighing 8 lb 5 oz (3.8 kg). During the mother's pregnancy, occasional bleeding, infection of the external genitalia, and anemia were observed. The rest of the child's history was uneventful except for pneumonia at the age of 1 month and chronic asthma.Physical examination revealed a slightly somatically retarded child (Fig 1) weighing 36 lb 4 oz (16.4 kg), within the sixth percentile, and with a height of 39½ inches (100.3 cm), below the
Maganias NH, Archambault L, Becker KL, Winnacker JL. A 1/G Translocation in a Member of a Kindred With a Marker Chromosome. Arch Intern Med. 1967;119(3):297-301. doi:10.1001/archinte.1967.00290210129013