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June 1967

An Unusual Case of Macroglobulinemia

Author Affiliations


From the Department of Internal Medicine, the University of Texas Southwestern Medical School and Radioisotope Unit, Veterans Administration Hospital, Dallas. Dr. Wood is presently in Fort Sill, Okla.

Arch Intern Med. 1967;119(6):631-637. doi:10.1001/archinte.1967.00290240153016

THE MACROGLOBULINEMIA of Waldenström, once considered to be rare,1 has now been noted with ever increasing frequency. Although 360 case reports have been published, the present report of a single case is noteworthy because of the very unusual and instructive course which it followed. After an apparently typical course for over three years this man's paraprotein began to decrease, and he developed multiple lymphoblastic lymphosarcomatous masses in unusual sites. Two of these masses, in the stomach and prostate gland contributed significantly to the clinical problems encountered in the last months of the patient's life. The evolution of this patient's final illness demonstrates that these unusual masses can, at times, be of vital clinical significance. A brief review of the fifty reported cases of macroglobulinemia with lymphomatous masses is presented, and the significance of this association is discussed.

Report of a Case  A 66-year-old white man (DVAH A18562) was first

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