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Primary carcinoma of the liver can no longer be regarded as a clinical curiosity rarely encountered in temperate climes, which usually escapes ante mortem recognition and for which no effective treatment can be offered.
This view is implicit in this monograph by Leon-Sotomayor and Moore. They observed 30 cases in a ten-year period at the Johns Hopkins Hospital and cite recent figures that show the incidence of hepatic carcinoma to be increasing. It now approaches 1% (0.6% to 1.9%) of necropsies in the United States. The feasibility of ante mortem diagnosis is evident in their personal series; 80% of their cases were recognized during life.
The purpose of this monograph is to enhance (1) awareness of the manifestations of hepatic carcinoma and (2) means for establishing the diagnosis. To this end, it provides a thorough account of the clinical features of this condition and a separate presentation of "unusual clinical
Zimmerman HJ. Unusual Clinical Features of Cirrhosis and Primary Liver Cell Carcinoma.. Arch Intern Med. 1967;120(2):252-253. doi:10.1001/archinte.1967.00300020124023