January 1968

Host Enzyme Induction of Bacterial Infection

Author Affiliations

Baltimore and Frederick, Md

From the Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, and the US Army Medical Unit, Fort Detrick, Frederick, Md. Doctor Lust is now at the Max-Planck-Institute fur Zellchemie, Karlstrasse 23, 8 Munchen 2, Germany.

Arch Intern Med. 1968;121(1):11-16. doi:10.1001/archinte.1968.03640010013002

Early in the course of experimental pneumococcal infection in mice, a significant induction of the liver enzyme, tryptophan pyrrolase, occurs. The importance of endogenous adrenal secretions in producing enzyme induction was demonstrated. Changes in total liver protein synthesis during infection may parallel to a degree changes in tryptophan pyrrolase production and are also based on normal adrenal function. Alterations in these two apparently related phenomena indicate that a protein anabolic phase occurs during the course of experimental pneumococcal infection. The importance of these changes is discussed in terms of normal host defense mechanisms.