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Article
January 1968

Clinical Evaluation of Cephaloridine

Author Affiliations

Boston

From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston. Doctors Steigbigel and Kislak were postdoctoral research fellows of the National Institute of Allergy and Infectious Diseases and research fellows in Medicine, Harvard Medical School. Doctor Steigbigel is now at Beth Israel Hospital, Boston; and Dr. Kislak is with the Department of Medicine, New York University College of Medicine, New York.

Arch Intern Med. 1968;121(1):24-38. doi:10.1001/archinte.1968.03640010026004
Abstract

Cephaloridine was used to treat 136 bacterial infections in 122 hospitalized patients. Its antibacterial and clinical effectiveness against serious staphylococcal infections compared favorably with that of cephalothin sodium and of penicillinase-resistant penicillins in similar cases. Cephaloridine was highly effective clinically and in eradicating the causative organisms in infections due to pneumococci, streptococci, Escherichia coli, and Proteus mirabilis; but its effectiveness against klebsielleae was variable. Superinfection with resistant gram-negative bacilli and serious noninfectious conditions were the major causes of most of the deaths. Injections of cephaloridine were remarkably well tolerated. Cross sensitization with penicillin was not encountered. Cephaloridine may have caused or contributed to acute renal failure and to an unusual coagulopathy, each observed in two patients. Cephaloridine is a highly effective and useful antibacterial agent when selected and used with due regard to its activity and potential nephrotoxicity.

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