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January 1968

Thrombohemorrhagic Phenomena.

Author Affiliations

St. Louis


By Hans Selye, MD. Price, $19.50. Pp 337, with 8 illustrations. Charles C Thomas, Publishers, 301-327 E Lawrence Ave, Springfield, Ill, 1966.

Arch Intern Med. 1968;121(1):110. doi:10.1001/archinte.1968.03640010112029

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The disseminated intravascular clotting syndromes (consumption coagulopathies, etc) are being recognized with increasing frequency among patients with a hemorrhagic diathesis, overt hemorrhage, thrombosis, or a combination of such findings. Interest in this problem has increased as our knowledge of these syndromes broadens, both in terms of clinical and laboratory manifestations. Since these disorders appear in a heterogeneous group of cases, it is quite likely that the mechanisms responsible for disseminated intravascular coagulation may be somewhat different in each, but as a group they provide clinical counterparts for a variety of animal observations which have been made in recent years. Included among these are:

1. The demonstration of the occurrence of intravascular clotting in severe forms of hemodynamic shock, antigen-antibody reactions, and following a variety of bacterial toxins.

2. The importance of intravascular coagulation in the Sanarelli-Schwartzman phenomen, both of the local and generalized types.

3. The striking effects of endotoxin

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