April 1968

Significance of Leukocyte Alkaline Phosphatase in Hodgkin's Disease

Author Affiliations


From the Yamins Research Laboratory of the Beth Israel Hospital (Drs. Bennett and Rutenburg), and the Children's Cancer Research Foundation (Dr. Nathanson), and from the departments of surgery and medicine, Beth Israel Hospital, and Harvard Medical School, Boston. Doctor Bennett is presently with Hematology Service of the Clinical Pathology Department, National Institutes of Health, Bethesda, Md.

Arch Intern Med. 1968;121(4):338-341. doi:10.1001/archinte.1968.03640040032006

In a long-term prospective study of leukocyte alkaline phosphatase (LAP) activity in patients with advanced Hodgkin's disease, there was an excellent correlation between LAP activity and "active" disease in the absence of known corticosteroid therapy and major infection. Most patients with 'inactive" disease had normal LAP activity. Serial measurements of LAP activity appear to be a useful adjunct in evaluating not only the clinical state of patients with Hodgkin's disease but also their response to therapy.