Iron deficiency anemia is by far the most common of the hypochromic microcytic anemias, but in recent years at least six other hypochromic syndromes have been described, the most common of which is thalassemia.1 The thalassemia syndromes are being recognized more frequently, and it is now known that they occur commonly in Southern Asia and the Middle East, as well as in the Mediterranean countries. With increasing migration of these population groups, thalassemia will be seen with greater frequency.
Thalassemia syndromes, characterized by a mild anemia, mild morphological changes in the peripheral red blood cells (RBC), and slight splenomegaly, usually cause no symptoms or are associated with mild fatigue. This process has been characterized as being completely benign and free of complications. It is the purpose of this report to examine the significance of excessive iron storage in the thalassemia "minor" syndromes and to report a case of hemosiderosis
Williams CE, Siemsen AW. Hemosiderosis in Association With Thalassemia Minor. Arch Intern Med. 1968;121(4):356-360. doi:10.1001/archinte.1968.03640040050011