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April 1968

Transport und Funktion Intracellulärer Elektrolyte.

Arch Intern Med. 1968;121(4):388. doi:10.1001/archinte.1968.03640040082046

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Ussing's "frog skinnery" is influencing fundamental concepts of medicine today. Transactions of the symposium on the transport and function of intracellular electrolytes held in Schüren, Germany, in June 1967 already reached my hands in October. Forty-one physicians and other scientists contributed observations extending the pioneering work of Ussing (Denmark), Bergström (Sweden), and Boulpaep (Belgium) to the physiology of liver, kidney, intestine, brain, muscle, and the hematopoetic system. Demonstration of the close correlation between electrochemical function and the minute anatomy shows the decisive role of the cell membrane in the matters of life and death.

Ussing extended his ingenious experiments on frog skin epithelium to demonstrate the exact mechanisms involved in active transport of sodium and to record the electro-potentials generated by it. Previously, Bergström had pioneered in the analysis of the intracellular electrolyte content; at this symposium he added evidence to show a correlation between muscular glycogen and potassium content

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