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June 1968

Diagnostic Cell Pathology in Tissue and Smears.

Author Affiliations


Arch Intern Med. 1968;121(6):579-580. doi:10.1001/archinte.1968.03640060093032

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Among pathologists there is an old saying: "High power microscopy, low power pathology." This approach works well in tissue work; but according to the author of this text, it makes cytology reports unnecessarily vague. If I correctly interpret his book, he would adapt the adage to read as follows: "Oil immersion microscopy, high power cytology."

Doctor Nieburgs, a pathologist at Mount Sinai School of Medicine, has scrutinized hematoxylin and eosin stained cells under the oil immersion lens for 12 years. This technic, he says, lets him look closely enough at the nucleus to sharply differentiate benign and malignant cells. He uses criteria he calls MAC (malignancy associated changes). These include nuclear cytoplasmic ratio, chromocenters and chromatin bands, nuclear clear areas, nucleoli, and multinucleated cells. Once he has studied these, he reports diagnoses "... in terms of pathological tissue alterations."

In other words (and here it seems to me is his main

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