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The application of body fluid enzyme determinations to diagnostic and pathophysiological problems, which traces its history to the observations of Wohlgemuth 60 years ago, has become an increasingly popular and productive pursuit for clinical biochemists and biochemically oriented clinicians over the last two decades. The effluence from veins, subarachnoid spaces, and urethras without number has fed an ever enlarging pool of information contained in case reports, research papers, review articles, and monographs. But surely few laboratories around the world can equal the record of diligence and perseverance contained in this critical analysis of over 300,000 assays in serum carried out during several years in the cantonal hospital of the ancient Swiss city of St. Gallen.
The authors have chosen to present their extensive experience (based on the determination of up to 18 enzymes and several other chemical constituents in 25,000 sera) as a sequence of enzyme patterns for representative cases
Hirschberg E. Atlas der Klinischen Enzymologie.. Arch Intern Med. 1968;122(2):189. doi:10.1001/archinte.1968.00300070093032