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September 1968

Acute Renal Failure in Plasmodium falciparum MalariaTreatment by Peritoneal Dialysis

Author Affiliations

USA; USA; Washington, DC

From the Walter Reed Army Institute of Research, Washington, DC, and the Third Field Hospital, Vietnam. Dr. Miller is now at Columbia University School of Public Health, New York; Dr. Eichler is now at the New Jersey College of Medicine and Dentistry, Jersey City; and Dr. Barry is now at the Washington Hospital Center, Washington, DC.

Arch Intern Med. 1968;122(3):199-203. doi:10.1001/archinte.1968.00300080007002

Two patients with renal failure due to heavy infection with Plasmodium falciparum were successfully treated by peritoneal dialysis. Rapid clinical deterioration precluded safe transfer to a hemodialysis facility. The efficiency of peritoneal dialysis, although less than in other forms of renal failure, was sufficient to control the clinical and biochemical manifestations of renal failure. Quinine in combination with other antimalarial drugs was successful in doses less than usually employed for the chloroquine-resistant species of southeast Asia. No accumulation of quinine occurred in the one patient studied. However, a reduced dosage should be employed under these circumstances.