Low or distinctly abnormal bone density values as determined by iodine 125 bone densitometry of a middle phalanx have been found in 15 of 20 patients with primary hyperparathyroidism. Conventional radiologic techniques revealed abnormalities in only four patients. A progressive decline in bone density in the nine months prior to surgery was observed in one patient and increasing bone densities were found in the three patients studied from 12 to 22 months postsurgery. These findings confirm the high frequency of subclinical bone demineralization in hyperparathyroidism and support the sensitivity of this method for bone density evaluation.
Forland M, Strandjord NM, Paloyan E, Cox A. Bone Density Studies in Primary Hyperparathyroidism. Arch Intern Med. 1968;122(3):236–240. doi:10.1001/archinte.1968.00300080044009