October 1968

A Biological Consideration of Treatment of Breast Cancer.

Author Affiliations



By George Crile, Jr., MD, FACS. Price, $8. Pp 189, with 21 illustrations. Charles C Thomas, Publisher, 301-327 E Lawrence Ave, Springfield, Ill 62703, 1967.

Arch Intern Med. 1968;122(4):382. doi:10.1001/archinte.1968.00300090092031

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This is an interesting and provocative monograph which is not recommended for the general medical reader, although the surgeon, radiotherapist, and physician who are interested in carcinoma of the breast will find it worth perusing. The essential point which the author propounds is that the primary treatment of carcinoma of the breast should be more conservative than the conventional radical mastectomy, with or without postoperative irradiation.

Most of the evidence (including his own experience) which he cites is not based on prospective, randomly-controlled, clinical trials, and hence must be regarded on scientific grounds as being inconclusive information; some exceptions to this statement are the controlled studies of Paterson and Russell, Nissen-Meyer, Kaae, and Johansen. These papers are included in the bibliography and are "musts" for those interested in the subject of breast cancer.

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