January 1969

Folate Losses From the Skin in Exfoliative Dermatitis

Author Affiliations


From the Department of Medicine, School of Medicine, University of Pennsylvania, and the Hematology Section of the Medical Clinic, Hospital of the University of Pennsylvania, Philadelphia. Doctor; Hild was a fellow of the American Cancer Society. He is now with the Department of Medicine, Hartford Hospital, Hartford, Conn.

Arch Intern Med. 1969;123(1):51-54. doi:10.1001/archinte.1969.00300110053009

Nine patients with chronic exfoliative dermatitis were studied in order to delineate the problem of folate loss and absorption in this condition. Low serum folate activity was found in six patients. The folate content of exfoliated skin was compared with values obtained from normal skin, and a four- to six-fold increase was observed. At least 5μg to 20μg of folate activity were lost daily in the exfoliated skin from these patients. The gastrointestinal absorption of folic acid was normal in the three patients in which this was studied. It is shown that significantly large folate losses occur from skin sloughing in exfoliative dermatitis.