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March 1969

Studies on the Role of Adenylcyclase in Insulin Secretion

Author Affiliations

Durham, NC

Arch Intern Med. 1969;123(3):248-251. doi:10.1001/archinte.1969.00300130030005

The administration of glucose, tolbutamide, corticotropin, and glucagon to mice resulted in stimulation of insulin secretion. These stimulations were all inhibited by the prior administration of β-adrenergic receptor blocking agents. Cyclic 3',5' adenosine monophosphate stimulated insulin secretion in intact mice and its stimulatory effect was also inhibited by β-adrenergic receptor blocking agents. The locus of the inhibitory effects of β-adrenergic receptor blocking agents on insulin secretion is discussed.