[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
August 1969

Familial Cold UrticariaA Generalized Reaction Involving Leukocytosis

Author Affiliations

Durham, NC

From the divisions of dermatology and hematology, Duke University Medical Center, Durham, NC.

Arch Intern Med. 1969;124(2):129-134. doi:10.1001/archinte.1969.00300180001001

Studies of a family with "familial cold urticaria" indicate that the syndrome is not a true urticarial disorder, but appears to be a systemic reaction generated by cooling of the skin. The systemic reaction appears to be mediated by an unidentified humoral substance, probably not histamine. Leukocytosis is a constant accompaniment of the generalized reaction and seems to play a role in the pathogenesis of the skin lesions. The generalized reaction can be prevented by the prior administration of Pseudomonas polysaccharide complex (Piromen).