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March 1970

Single-Dose Metyrapone Test

Author Affiliations

Salt Lake City

From the Laboratory for the Study of Hereditary and Metabolic Disorders, the Department of Medicine and the Clinical Research Center, University of Utah College of Medicine, Salt Lake City.

Arch Intern Med. 1970;125(3):472-474. doi:10.1001/archinte.1970.00310030082008

For a single-dose metyrapone test, from 2 to 3 gm of the drug were given at midnight. Blood for plasma deoxycortisol and adrenocorticotropic hormone determination was obtained at 8 AM the next morning. Urine for assay of 11-deoxycorticosteroids was also collected from midnight to midnight before and after metyrapone administration. Using any of the three determinations, we found no overlap between 30 normal subjects and 11 patients with pituitary insufficiency. The results are comparable to those obtained with the standard metyrapone test (750 mg every four hours, six times). We conclude that the single-dose metyrapone test is a simple and reliable test of pituitary function.