March 1970

Acute Granulocytic Leukemia Complicating Hodgkin's Disease

Author Affiliations


From the Blood Research Laboratory, New England Medical Center Hospitals, and the Department of Medicine, Tufts University School of Medicine, Boston.

Arch Intern Med. 1970;125(3):496-498. doi:10.1001/archinte.1970.00310030106013

The coexistence of acute leukemia and Hodgkin's disease is rare.1 However, Crosby 2 in a recent survey estimated the incidence of acute granulocytic leukemia in Hodgkin's disease to be increased tenfold, and suggested that this may be a sequel to radiotherapy, not directly related to the disease. We present here two patients with Hodgkin's disease of long duration, in both of whom acute leukemia developed. A refractory sideroblastic anemia, which rapidly progressed to erythroleukemia (acute Di Guglielmo syndrome) developed in one; pancytopenia developed in the other, who died of acute granulocytic leukemia nine months later.

Patient Summaries  In 1954, a 36-year-old woman had Hodgkin's disease involving cervical, supraclavicular, and mediastinal nodes. She received radiotherapy (2,400 roentgens) to these areas. Laboratory values were as follows: hemoglobin, 12.4 gm/ 100 ml; leukocytes, 9,100/cu mm, with 58% neutrophils, 21% lymphocytes, 16% monocytes, and 5% eosinophils. In 1960, adenopathy recurred, with systemic symptoms.

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