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Article
April 1970

Angiographic Identification of Enteric LesionsGuide to Therapy in Hereditary Hemorrhagic Telangiectasis

Author Affiliations

Morgantown, WVa

(Drs. Campbell and Jewson) and pathology (Dr. Gilbert), West Virginia University Medical Center, Morgantown.

Arch Intern Med. 1970;125(4):705-707. doi:10.1001/archinte.1970.00310040129017
Abstract

Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome, HHT) is defined as a familial autosomal recessive disease characterized by telangiectasia of skin and mucous membrane vessels tending to manifest bleeding increasingly after the third decade. Lesions have been described as elevated and nodular, simple spiders, violaceous macular, with the most common form being a 1- to 3-mm punctiform nonelevated, purple telangiectasis.1-3 Documented involvement has included pulmonary, meningeal, cerebral, renal, hepatic, ocular, and aortic lesions in addition to the more frequent dermal and oral manifestations.3,4

With gastrointestinal bleeding, peptic ulcer may be suspected and both conditions may in fact coexist.5 Enteric telangiectasia cannot be demonstrated by studies after barium administration, and direct visualization carries the risk of inducing hem

Received for publication Nov 14, 1969; accepted Dec 30.

From the departments of medicine orrhage. Blind surgical approach frequently may not locate the bleeding site. The complication of repeated hemorrhage and severe

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