Experimental models are used to study the defense of the lung to infectious agents. The various lung defense mechanisms are chiefly the mechanical clearance brought about by the mucus transport and bronchial clearance brought about by pulmonary macrophages. From the effects on these mechanisms after exposure to environmental agents it is concluded that a deficiency in either of the mechanisms will lead to conditions favorable for the development of disease. The experimental models used for the study of the defense mechanisms are discussed in view of their functional importance and possible changes present after exposure to environmental agents.
Rylander R. Studies of Lung Defense to Infections in Inhalation Toxicology. Arch Intern Med. 1970;126(3):496-499. doi:10.1001/archinte.1970.00310090126016