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October 1970

Amyloid Coronary Artery Disease, Primary Systemic Amyloidosis and Paraproteinemia

Author Affiliations

Bethesda, Md

From the Pathologic Anatomy Branch, National Cancer Institute (Dr. Barth), the Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases (Drs. Willerson and Decker), and the Section of Pathology, National Heart and Lung Institute (Drs. Buja and Roberts), Bethesda, Md. Dr. Barth is now with the University of Kansas Medical Center, Kansas City, and Dr. Willerson is now with the Massachusetts General Hospital, Boston.

Arch Intern Med. 1970;126(4):627-630. doi:10.1001/archinte.1970.00310100073007

A patient had primary systemic amyloidosis with severe cardiac involvement and IgG paraproteinemia. Numerous intramural coronary arteries were occluded by amyloid deposits, but arteriosclerosis of the extramural arteries was absent. The amyloid coronary artery disease was associated with angina pectoris, a myocardial infarct, and mural thrombi which resulted in cerebral, renal, pulmonic, and coronary arterial emboli.