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The purpose of this book is to present the biochemical under-pinnings on which a great number of clinical procedures are based, both in diagnosis and as a guide to therapy. On that score it is superb.
The present edition does not differ basically from the splendid third edition, except that it is updated from 1964. One of my favorite topics, carbohydrate metabolism, did indeed require updating due to recent changes in our understanding of diabetes, insulin, etc. The orientation is predominantly clinical, but it offers sufficient data on basic mechanisms to give the subject wholeness. The emphasis is on the practical that may be encountered any day. For example, Hoffman does not take space to argue whether hypoglycemia is or is not a clinical entity, but he outlines briefly its varieties or types and what actually happens. In the same fashion, he presents blood clotting, diabetes, and several other phenomena
Di Cyan E. The Biochemistry of Clinical Medicine, ed 4.. Arch Intern Med. 1970;126(4):704. doi:10.1001/archinte.1970.00310100150028