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November 1970

The Nature of Vitamin D Resistance in Experimental Uremia

Author Affiliations

Boston; New York; Boston

From the departments of medicine, Harvard Medical School and Beth Israel Hospital Boston (Dr. Kimberg and Miss Gershon) and Columbia University College of Physicians and Surgeons, New York (Dr. Baerg).

Arch Intern Med. 1970;126(5):891-895. doi:10.1001/archinte.1970.00310110161029

The diminished absorption of calcium and the osteodystrophy which accompany chronic renal disease are often "resistant" to vitamin D. The basis for this resistance remains uncertain. Recent studies have emphasized the role of an abnormality in vitamin D metabolism in accounting for the alterations in calcium absorption and the apparent vitamin D resistance which occur in renal failure. The results of experiments in this laboratory with a uremic animal model strongly suggest that in addition to the proposed mechanism involving an interference with the metabolism of vitamin D, renal insufficiency also affects the cellular reactions mediating calcium transport in a manner which, while opposite in direction to that of vitamin D, is independent of a direct interaction with the vitamin or its metabolites.