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April 1971

Studies of the Retinal Circulation in ManObservations on Vessel Diameter, Arteriovenous Oxygen Difference, and Mean Circulation Time

Author Affiliations

From the Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana.

Arch Intern Med. 1971;127(4):688-702. doi:10.1001/archinte.1971.00310160166012

SYSTEMIC DISORDERS often cause pathological changes in the optic fundus. These changes have diagnostic value because of their empirical association with specific illnesses. The value of funduscopic examination would be even further increased by a better understanding of how certain of these fundic lesions are produced. With the ultimate object of investigating this problem, several photographic techniques for study of the retinal circulation and metabolism in man have been adapted or developed and used by the authors and their associates. These techniques are: (1) measurement by fundus photography of changes in the diameter of retinal vessels in response to various stimuli, a procedure previously used by others;1,2 (2) estimation by fundus photography of the arteriovenous blood oxygen difference, (3) a method of photographing fluorescence in circulating blood in the retina, and ( 4) a method for measuring the mean retinal circulation time using fluorescein. It is the purpose of this

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