June 1971

Peroxidative Metabolism in Alveolar Macrophages

Author Affiliations

New Haven, Conn; Pittsburgh

From the Department of Medicine, Yale University School of Medicine, New Haven, Conn (Dr. Gee) and the departments of medicine and biochemistry, University of Pittsburgh School of Medicine, Pittsburgh (Drs. Vassallo, Vogt, and Basford and Catherine Thomas).

Arch Intern Med. 1971;127(6):1046-1049. doi:10.1001/archinte.1971.00310180062008

The effects of phagocytosis on the metabolic responses of rabbit alveolar macrophages have been studied in vitro. These cells exhibit peroxidative metabolism which is stimulated phagocytosis. One H2O2 generating oxidase, D-amino acid oxidase, has been demonstrated. Two H2O2 utilizing pathways exist, namely a nicotinamide adenine dinucleotide phospate (NADP) linked cytoplasmic glutathione shuttle and catalase-dependent reactions.