Breathing pure oxygen at one atmosphere leads to primary destruction of alveolar capillary endothelial cells; squamous epithelial cells are damaged secondarily, whereas granular pneumocytes are found to regenerate a cuboidal epithelium lining and air spaces. Interstitial and alveolar edema ensue as a consequence of permeability changes in the cell layers. The role of hematological changes in the development of pulmonary oxygen toxicity is discussed.
Weibel ER. Oxygen Effect on Lung Cells. Arch Intern Med. 1971;128(1):54-56. doi:10.1001/archinte.1971.00310190058005