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July 1971

Oxygen Effect on Lung Cells

Author Affiliations

Bern, Switzerland

From the Department of Anatomy, University of Berne, Switzerland.

Arch Intern Med. 1971;128(1):54-56. doi:10.1001/archinte.1971.00310190058005

Breathing pure oxygen at one atmosphere leads to primary destruction of alveolar capillary endothelial cells; squamous epithelial cells are damaged secondarily, whereas granular pneumocytes are found to regenerate a cuboidal epithelium lining and air spaces. Interstitial and alveolar edema ensue as a consequence of permeability changes in the cell layers. The role of hematological changes in the development of pulmonary oxygen toxicity is discussed.