The finding of suprasellar calcification in a young male with diabetes insipidus and selective anterior putuitary insufficiency suggests the presence of a craniopharyngioma. However, calcifications at the base of the brain are common in patients successfully treated for tuberculous meningitis1-5 and both pituitary insufficiency and precocious puberty have been described as sequelae to cured tuberculous meningitis.6-8
Haslam et al9 have recently reported a patient with suprasellar calcifications who developed diabetes insipidus, growth failure, and hypogonadism following the successful treatment of tuberculous meningitis. We have studied a patient with similar hormonal deficiencies and intracranial calcifications occurring several years after the successful treatment of tuberculous meningitis. A suprasellar mass and hydrocephalus were excluded as causes of the hormonal deficiencies. This case further documents localized involvement by the tuberculous process as the cause of the endocrine syndrome.
A 17-year-old Potawatomi Indian boy was referred to the Clinical Center
Sherman BM, Gorden P, di Chiro G. Postmeningitic Selective Hypopituitarism With Suprasellar Calcification. Arch Intern Med. 1971;128(4):600-604. doi:10.1001/archinte.1971.00310220108017