October 1971

Transmission of an Active Agent From Rheumatoid Arthritis Synovial Tissue to Chicks

Author Affiliations

Los Angeles

From the Orthopedic Division, Department of Surgery (Drs. Warren and Marmor and Mrs. Liebes), the departments of medical microbiology and immunology, and pediatrics, School of Medicine, and the School of Public Health (Dr. Boak), Center for the Health Sciences, University of California, Los Angeles.

Arch Intern Med. 1971;128(4):619-622. doi:10.1001/archinte.1971.00310220127021

In order to confirm and amplify the evidence of a transmissible agent in human rheumatoid arthritis (RA) tissue reported in mice experiments, data are presented indicating the transmission of the RA agent from this tissue to chicks as well as from chick to chick and by congenital transmission. Chicks hatched from injected embryonated eggs show clearly identifiable redness of the feet, talipes deformities, and dislocation of the hip. Control embryonated eggs hatched normal chicks. Roentgenograms showed developmental defects of the cervical, thoracic, lumbar, and sacral vertebrae. The chick embryo may provide an avenue to further examine the infectious etiology of RA.