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October 1971

Radiation Biology Juvenile Mammal.

Author Affiliations

Pasadena, Calif


Edited by Melvin R Sikov, MD, D Dennis Mahlum, MD. Price, $3. Pp 1,026, with many illustrations. US Atomic Energy Commission, Division of Technical Information Extension, PO Box 62, Oak Ridge, Tenn 37830, 1969.

Arch Intern Med. 1971;128(4):645. doi:10.1001/archinte.1971.00310220153034

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No diminished interest in the biological effects of irradiation has occurred since Muller demonstrated the mutagenic potentialities of x-rays. This volume is a collection of papers presented at the Ninth Annual Hanford Biology Symposium, Radiation Biology of the Fetal and Juvenile Mammal, cosponsored by Battelle Memorial Institute-Pacific Northwest Laboratories and the US Atomic Energy Commission.

Because there are nearly 90 reports in just over 1,000 pages, excluding remarks of the chairmen, the reports are generally brief. This necessity for brevity may be responsible for the uneven character of the papers. More extensive development of papers could well have made many more informative.

As a mutagen, ionizing radiation has a multiple potential for disease production: by solitary gene-effects it may simulate hereditary disorders; or, by another mechanism, affect karyokinesis and produce cytogenetic abnormalities. Effects on genes during development implies the potential for diverting differentiation; also, there are the oncogenic aspects, another

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