[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
November 1971

Screening for Adrenocortical Insufficiency With Cosyntropin (Synthetic ACTH)

Author Affiliations

Los Angeles

From the Department of Medicine, University of Southern California School of Medicine and the Los Angeles County-University of Southern California Medical Center, Los Angeles.

Arch Intern Med. 1971;128(5):761-763. doi:10.1001/archinte.1971.00310230091007

A screening procedure for adrenocortical insufficiency, utilizing (synthetic a 1-24 adrenocorticotropic hormone [ACTH] and a cortisol-binding globulin technique for serum cortisol, has been evaluated in normal subjects and in patients with primary and secondary adrenal insufficiency. Cosyntropin is injected by vein, and a serum cortisol concentration 60 minutes later is compared with a sample removed just prior to the cosyntropin administration. A clear separation of normal subjects from those with adrenal insufficiency is achieved.