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November 1971

Schönlein-Henoch Syndrome Associated With Exposure to Cold

Author Affiliations

Fort Sam Houston, Tex

From the departments of medicine and pathology, Brooke General Hospital and the Metabolic Branch, US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Tex.

Arch Intern Med. 1971;128(5):782-786. doi:10.1001/archinte.1971.00310230112011

The terms Schönlein-Henoch syndrome or anaphylactoid purpura have been applied to a specific acquired hemorrhagic disorder without abnormalities of the clotting mechanism or evidence of thrombocytopenia. This syndrome is characterized by a generalized vasculitis involving multiple organ systems.1 The etiology and pathogenesis of this syndrome are unknown, though rare cases are associated with food allergy and drugs,2,3 or insect bite.4 The demonstration of granular and nodular deposits of IgG and β1C globulin located primarily in the mesangium and to a lesser degree on the basement membrane of glomeruli of patients with this syndrome5 suggests an immune pathogenesis. Histologic and ultrastructural features of the glomerular lesions, including prominent deposition of platelets and fibrin in the capillary lumen5 do not specifically distinguish anaphylactoid purpura from other forms of immune renal disease such as acute poststreptococcal glomerulonephritis, systemic lupus erythematosus, and Goodpasture's syndrome8; however, normal serum complement levels6-7 help to distinguish anaphylactoid purpura

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