December 1971

internal at large medicine

Arch Intern Med. 1971;128(6):859-871. doi:10.1001/archinte.1971.00310240013001

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Alcohol and atherosclerosis  Moderate drinking can hasten the progress of atherosclerosis in some individuals, according to a preliminary study by a group of Pennsylvania investigators.Alcohol has not been singled out as a specific causal factor in the genesis of atherosclerosis, "but an alcoholinduced augmentation of underlying genetic-metabolic hyperlipoproteinemia appears to play an important role in sustaining a persistent—and perhaps in contributing toward—arterial deterioration," said Peter T. Kuo, MD, at the third annual Western Nutrition Congress in Miami.The data have not been fully analyzed, Dr. Kuo stressed, but preliminary observations suggest that alcohol restriction is "... of prime importance in the successful control of the great majority of atherosclerosis- and arteriosclerosis-prone patients who have elevated serum lipid levels."Dr. Kuo, professor of medicine at the Hospital of the University of Pennsylvania, based his hypothesis on two related studies that led to strikingly similar results. One study dealt with 125 randomly

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