[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
January 1972

A Simple and Reliable Test for the Diagnosis of Hyperparathyroidism

Author Affiliations

Bethesda, Md

From the Section on Mineral Metabolism, Endocrinology Branch, National Heart and Lung Institute, Bethesda, Md.

Arch Intern Med. 1972;129(1):48-55. doi:10.1001/archinte.1972.00320010052004

Factors affecting the level of urinary excretion of phosphorus following a four-hour intravenous infusion of calcium were examined. Changes in amount of urinary phosphorus excretion during the second half of the calcium infusion day, were compared to those of the corresponding period of the control day in 20 patients with hyperparathyroidism and 22 normal subjects. Responses to calcium infusion differed in the two groups of subjects. In normal patients phosphorus excretion was decreased by > 29%, in hyperparathyroid patients by < 25%. Since mechanisms other than parathyroid depression may decrease phosphorus excretion during the first 12 hours after calcium infusion, the second 12-hour period is more suitable for evaluating parathyroid function.