July 1972

Cortisol Production by Testicular Tumors in Adrenogenital Syndrome

Author Affiliations

Portsmouth, Va; Nashville, Tenn; Portsmouth, Va

From the departments of medicine (Drs. Fore and Weber) and urology (Drs. Akers and Brooks), US Naval Hospital, Portsmouth, Va, and the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Dr. Fore is now a practicing physician in Greenville, NC; Dr. Bledsoe is presently an Assistant Professor of Medicine at Johns Hopkins Hospital, Baltimore; and Dr. Weber is now with the US Naval Hospital, Seattle.

Arch Intern Med. 1972;130(1):59-63. doi:10.1001/archinte.1972.03650010047009

A patient had bilateral testicular tumors complicating the adrenogenital syndrome. This is the first such instance of the complication fully documented to have occurred with the simple virilizing type of congenital virilizing adrenal hyperplasia (CAH) and the first demonstration of cortisol synthesis by the testicular tumors associated with this disorder. A review of the literature concerned with the origin of these testicular tumors suggests that they arise primarily from testicular interstitial cells under the stimulus of increased plasma adrenocorticotropic hormone (ACTH).