July 1972

Nonviral Hepatitis in Patients Maintained by Long-Term Dialysis

Author Affiliations


From the departments of medicine (Drs. Bergman, Reddy, Ellison, Smith, and Dunea) and pathology (Dr. Thomas), Chicago Medical School/University of Health Sciences; Division of Renal Disease, departments of medicine (Drs. Bergman, Reddy, and Ellison) and pathology (Dr. Thomas), Mount Sinai Hospital Medical Center; and the departments of medicine (Dr. Smith) and renal disease (Dr. Dunea), Cook County Hospital, Chicago. Dr. Reddy is now with Wadsworth VA Hospital, Los Angeles.

Arch Intern Med. 1972;130(1):96-100. doi:10.1001/archinte.1972.03650010082015

The significance of elevated plasma transaminase levels was studied in a group of patients maintained by long-term dialysis. All but one had a nonspecific hepatitis with predominantly lymphocytic infiltration in the portal triads and scattered foci of liver cell necrosis. The histological picture was not that of viral hepatitis and Australia antigen was not found in the serum. We conclude that patients maintained by long-term dialysis develop a nonspecific hepatitis associated with elevated serum glutamic pyruvic transaminase levels, which appears not to be viral in etiology.