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Douglas has been eminently successful in his stated goal of presenting the problems involved in establishing an experimental model to study toxemia of pregnancy. It is obvious that his interests are not vicarious as evidence of his own work is seen throughout the monograph.
The book is well organized, concise, and includes an excellent and current bibliography with each chapter. The illustrative material is pertinent and readily interpreted in conjunction with the text. Aspects of experimental design utilized in the author's laboratory certainly stress the need for rigid control on a prospective basis.
The question of whether research observations in any animal model below that of primate are analogous to the human continually nags at the reader; this is touched upon by Douglas. The problems posed in establishing primate and/or human research models, however, would almost preclude any continued effort in studying this perplexing and challenging disorder.
Perhaps the only
Pearson JW. Experimental Approaches to Toxemia of Pregnancy.. Arch Intern Med. 1972;130(1):158. doi:10.1001/archinte.1972.03650010136046