[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.65.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
September 1972

Pharmacokinetics of Procainamide

Author Affiliations

Denver

From the Department of Medicine, University of Colorado Medical Center, Denver.

Arch Intern Med. 1972;130(3):366-369. doi:10.1001/archinte.1972.03650030046011
Abstract

Routes, mechanisms, and magnitude of procainamide hydrochloride excretion were examined. In normal man and dogs, renal excretion averaged 65% in 6 hours and 90% in 12 hours and mean plasma half-time was 2.85 ± 0.25 hours. Patients with renal disease had prolonged plasma half-time (5.85 ± 0.62 hours; P <.001) and decreased sixhour urine excretion (40.8 ± 1.8%; P <.001). Excretion was directly related to creatinine clearance. In experimental animals, increasing urine pH resulted in decreased renal procainamide clearance, but increasing urine flow rate with diuretics produced no change in clearance. Active biliary excretion occurred (bile plasma ratios—2.0) but total bile excretion and bile clearance were insignificant. Procainamide excretion is primarily renal and patients with renal impairment or alkalinized urine require reduced dosage.

×